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  • Repeat serum protein electrophoresis in 6 months and every 2–3 years thereafter if stable
  • No need for bone marrow biopsy or skeletal survey
  • BM biopsy with FISH
  • Consider CT abdomen if IgM monoclonal protein to exclude Waldenström Macroglobulinemia
  • LDH, β2 microglobulin, CRP
  • If all above are unremarkable, follow CBC serum protein electrophoresis, creatinine in 6 months, and then annually for life